解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In diploid Saccharomyces cerevisiae cells, bud-site selection is determined by two cortical landmarks, Bud8p and Bud9p, at the distal and proximal poles, respectively. Their localizations depend on the multigenerational proteins Rax1p/Rax2p. Many genes involved in bud-site selection were identified previously by genom...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.128231
更新日期:2011-08-01 00:00:00
abstract::We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling thos...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.128744
更新日期:2011-08-01 00:00:00
abstract::Self-incompatibility (SI) is a genetic system found in some hermaphrodite plants. Recognition of pollen by pistils expressing cognate specificities at two linked genes leads to rejection of self pollen and pollen from close relatives, i.e., to avoidance of self-fertilization and inbred matings, and thus increased outc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.127399
更新日期:2011-07-01 00:00:00
abstract::Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.128512
更新日期:2011-07-01 00:00:00
abstract::Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties "Misuzud...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.125062
更新日期:2011-06-01 00:00:00
abstract::Mitochondrial complex I is the largest multimeric enzyme of the respiratory chain. The lack of a model system with facile genetics has limited the molecular dissection of complex I assembly. Using Chlamydomonas reinhardtii as an experimental system to screen for complex I defects, we isolated, via forward genetics, am...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.128827
更新日期:2011-06-01 00:00:00
abstract::Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.127746
更新日期:2011-06-01 00:00:00
abstract::Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to mediate Notch target gene activation. This function of Pzg entails an...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.127795
更新日期:2011-05-01 00:00:00
abstract::The sequentially Markov coalescent is a simplified genealogical process that aims to capture the essential features of the full coalescent model with recombination, while being scalable in the number of loci. In this article, the sequentially Markov framework is applied to the conditional sampling distribution (CSD), ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.125534
更新日期:2011-04-01 00:00:00
abstract::Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly associated with stature in cattle (Bos taurus and Bos indicus). This suggests that these genes may contribute to control...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.123943
更新日期:2011-03-01 00:00:00
abstract::Brassica carinata, an allotetraploid with B and C genomes, has a number of traits that would be valuable to introgress into B. napus. Interspecific hybrids were created between B. carinata (BBCC) and B. napus (AACC), using an advanced backcross approach to identify and introgress traits of agronomic interest from the ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.124925
更新日期:2011-03-01 00:00:00
abstract::We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold. The bss phenotype...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.123299
更新日期:2011-02-01 00:00:00
abstract::Early embryogenesis in Drosophila melanogaster is controlled by maternal gene products, which are deposited in the egg during oogenesis. It is not well understood how maternal gene expression is controlled during germline development. pipsqueak (psq) is a complex locus that encodes several nuclear protein variants con...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.121624
更新日期:2011-02-01 00:00:00
abstract::Methodology for mapping quantitative trait loci (QTL) has focused primarily on treating the QTL as a fixed effect. These methods differ from the usual models of genetic variation that treat genetic effects as random. Computationally expensive methods that allow QTL to be treated as random have been explicitly develope...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.122333
更新日期:2011-01-01 00:00:00
abstract::Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.122754
更新日期:2011-01-01 00:00:00
abstract::We explore the effects of demography and linkage on a maximum-likelihood (ML) method for estimating selection and mutation parameters in a reversible mutation model. This method assumes free recombination between sites and a randomly mating population of constant size and uses information from both polymorphic and mon...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.122150
更新日期:2010-12-01 00:00:00
abstract::The range of possible gene interactions in a multilocus model of a complex inherited disease is studied by exploring genotype-specific risks subject to the constraint that the allele frequencies and marginal risks are known. We quantify the effect of gene interactions by defining the interaction ratio, CR=KR/KRI, wher...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.119008
更新日期:2010-12-01 00:00:00
abstract::Interchromosomal duplications are especially important for the study of X-linked genes. Males inheriting a mutation in a vital X-linked gene cannot survive unless there is a wild-type copy of the gene duplicated elsewhere in the genome. Rescuing the lethality of an X-linked mutation with a duplication allows the mutat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.123265
更新日期:2010-12-01 00:00:00
abstract::Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.117929
更新日期:2010-11-01 00:00:00
abstract::Evolution through natural selection suggests unnecessary genes are lost. We observed that the yeast Candida glabrata lost the gene encoding a phosphate-repressible acid phosphatase (PHO5) present in many yeasts including Saccharomyces cerevisiae. However, C. glabrata still had phosphate starvation-inducible phosphatas...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.120824
更新日期:2010-11-01 00:00:00
abstract::Genome-wide association mapping is a popular method for using natural variation within a species to generate a genotype-phenotype map. Statistical association between an allele at a locus and the trait in question is used as evidence that variation at the locus is responsible for variation of the trait. Indirect assoc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.121665
更新日期:2010-11-01 00:00:00
abstract::The Saccharomyces cerevisiae nuclear membrane is part of a complex nuclear envelope environment also containing chromatin, integral and peripheral membrane proteins, and large structures such as nuclear pore complexes (NPCs) and the spindle pole body. To study how properties of the nuclear membrane affect nuclear enve...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.119149
更新日期:2010-11-01 00:00:00
abstract::Centromeres control chromosome inheritance in eukaryotes, yet their DNA structure and primary sequence are hypervariable. Most animals and plants have megabases of tandem repeats at their centromeres, unlike yeast with unique centromere sequences. Centromere function requires the centromere-specific histone CENH3 (CEN...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.120337
更新日期:2010-10-01 00:00:00
abstract::This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.117622
更新日期:2010-09-01 00:00:00
abstract::Many arthropod species are infected with maternally inherited endosymbionts that induce a shift in the sex ratio of their hosts by feminizing or killing males (cytoplasmic sex-ratio distorters, or SRDs). These endosymbionts can have profound impacts on evolutionary processes of their hosts. Here, I derive analytical e...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.120014
更新日期:2010-09-01 00:00:00
abstract::Mutations in maternally transmitted symbionts can affect host fitness. In this study we investigate a mutation in an obligate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid hosts (Acyrthosiphon pisum). The heat-sensitive allele arises through a single base deletion in a ho...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.117440
更新日期:2010-09-01 00:00:00
abstract::Next generation sequencing (NGS) is about to revolutionize genetic analysis. Currently NGS techniques are mainly used to sequence individual genomes. Due to the high sequence coverage required, the costs for population-scale analyses are still too high to allow an extension to nonmodel organisms. Here, we show that NG...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.114397
更新日期:2010-09-01 00:00:00
abstract::While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years,...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.117200
更新日期:2010-08-01 00:00:00
abstract::Regulation of cytoskeletal structure and dynamics is essential for multiple aspects of cellular behavior, yet there is much to learn about the molecular machinery underlying the coordination between the cytoskeleton and its effector systems. One group of proteins that regulate microtubule behavior and its interaction ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.115626
更新日期:2010-08-01 00:00:00
abstract::Primary cilia have essential roles in transducing signals in eukaryotes. At their core is the ciliary axoneme, a microtubule-based structure that defines cilium morphology and provides a substrate for intraflagellar transport. However, the extent to which axonemal microtubules are specialized for sensory cilium functi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.116996
更新日期:2010-07-01 00:00:00
abstract::Sex-specific differences in dispersal, survival, reproductive success, and natural selection differentially affect the effective population size (N(e)) of genomic regions with different modes of inheritance such as sex chromosomes and mitochondrial DNA. In papionin monkeys (macaques, baboons, geladas, mandrills, drill...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.116228
更新日期:2010-07-01 00:00:00
abstract::The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.115014
更新日期:2010-07-01 00:00:00
abstract::The Drosophila melanogaster Chd3 gene encodes a member of the CHD group of SNF2/RAD54 ATPases. CHD proteins are conserved from yeast to man and many are subunits of chromatin-remodeling complexes that facilitate transcription. Drosophila CHD3 proteins are not found in protein complexes, but as monomers that remodel ch...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.115121
更新日期:2010-07-01 00:00:00
abstract::Obtaining accurate estimates of the genetic covariance matrix Sigma(G) for multivariate data is a fundamental task in quantitative genetics and important for both evolutionary biologists and plant or animal breeders. Classical methods for estimating Sigma(G) are well known to suffer from substantial sampling errors; i...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.113381
更新日期:2010-07-01 00:00:00
abstract::Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.115766
更新日期:2010-06-01 00:00:00
abstract::Initial events in double-strand break repair by homologous recombination in vivo involve homology searching, 3' strand invasion, and new DNA synthesis. While studies in yeast have contributed much to our knowledge of these processes, in comparison, little is known of the early events in the integrated mammalian system...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.115196
更新日期:2010-06-01 00:00:00
abstract::Biology is characterized by complex interactions between phenotypes, such as recursive and simultaneous relationships between substrates and enzymes in biochemical systems. Structural equation models (SEMs) can be used to study such relationships in multivariate analyses, e.g., with multiple traits in a quantitative g...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.112979
更新日期:2010-06-01 00:00:00
abstract::Genome stability in fission yeast requires the conserved S-phase kinase Hsk1 (Cdc7) and its partner Dfp1 (Dbf4). In addition to their established function in the initiation of DNA replication, we show that these proteins are important in maintaining genome integrity later in S phase and G2. hsk1 cells suffer increased...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.112284
更新日期:2010-05-01 00:00:00
abstract::Nonallelic gene conversion has been proposed as a major force in homogenizing the sequences of paralogous genes. In this work, we investigate the extent and characteristics of gene conversion among gene families in nine species of the genus Drosophila. We carried out a genome-wide study of 2855 gene families (includin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.115444
更新日期:2010-05-01 00:00:00
abstract::This Perspectives article recounts the isolation and sequencing of the first human histocompatibility gene (HLA) in 1980-1981. At the time, general knowledge of the molecules of the immune system was already fairly extensive, and gene rearrangements in the immunoglobulin complex (discovered in 1976) had generated much...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.110.113852
更新日期:2010-04-01 00:00:00